Gameplay continues in the same order until either the heroes have all been incapacitated or the villain is destroyed!
Note: there is no limit to the number of cards a player may have in hand or in play. If a deck ever runs out of cards, simply shuffle that deck's Trash, make it the new deck, and continue playing. You won't lose the game for a fiddly reason, like running out of cards or not having enough resources. You'll lose the game because a mad scientist pulled the moon into the earth, or a giant rampaging robot crushed you and your teammates!
Now get out there and save the Multiverse!