After selecting heroes, the players select a Villain and an Environment, placing the Villain deck and character cards in the Villain play area, and the Environment deck and the Environment play area.
Shuffle the Villain deck and the Environment deck.
The number in the top right corner of a Villain character card is that Villain's starting HP. Use the round tokens to track the Villain HP.
Then, follow all instructions in the "Setup" section of the Villain character card.
Now you're ready to play!